Last update
3/13/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.4
USERS' SCORE
Good
Based on 3 Reviews
8.2
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin E(as d-Alpha Tocopherol)
268 mg
1,787%
Top Medical Research Studies
9
We investigated whether vitamin E supplementation affects the risk of blood clots, specifically venous thromboembolism (VTE), in women. The Women's Health Study involved nearly 40,000 women who received either vitamin E or a placebo over more than ten years.
Our findings revealed that those taking vitamin E experienced a significant reduction in VTE occurrences compared to the placebo group. Notably, women with a history of VTE or certain genetic factors benefited the most from supplementation.
Overall, vitamin E may play a protective role against blood clots, offering promise for at-risk individuals.
Our findings revealed that those taking vitamin E experienced a significant reduction in VTE occurrences compared to the placebo group. Notably, women with a history of VTE or certain genetic factors benefited the most from supplementation.
Overall, vitamin E may play a protective role against blood clots, offering promise for at-risk individuals.
Read More
9
We explored how vitamin E affects blood clot breakdown in patients suffering from coronary spastic angina. In a well-structured study, 40 participants were split into groups receiving either vitamin E or a placebo over a month.
We observed that those who took vitamin E experienced significant improvements, with decreased levels of a key clotting factor and a marker for oxidative stress. This suggests that vitamin E may serve as an effective addition to treatments for managing coronary spasms, especially in patients without coronary atherosclerosis.
We observed that those who took vitamin E experienced significant improvements, with decreased levels of a key clotting factor and a marker for oxidative stress. This suggests that vitamin E may serve as an effective addition to treatments for managing coronary spasms, especially in patients without coronary atherosclerosis.
Read More
8
We explored how inducing heme oxygenase-1 (HO-1) could impact blood clot formation in a mouse model. Through a series of tests, we observed that mice treated with a HO-1 inducer showed a significant delay in thrombus formation.
This effect was linked to the production of bilirubin and carbon monoxide, which have protective roles in the bloodstream. Interestingly, when we used a vitamin E analogue, it almost entirely restored this delay in clotting. Overall, these findings suggest that enhancing HO-1 activity may offer a promising approach to prevent undesirable blood clots.
This effect was linked to the production of bilirubin and carbon monoxide, which have protective roles in the bloodstream. Interestingly, when we used a vitamin E analogue, it almost entirely restored this delay in clotting. Overall, these findings suggest that enhancing HO-1 activity may offer a promising approach to prevent undesirable blood clots.
Read More
Most Useful Reviews
7.5
Reduces arterial ridges
2 people found this helpful
Vitamin E seems to dissolve blood clots on arterial walls. I take it daily and highly recommend it.
Read More
7.5
Improved skin health
3 people found this helpful
I consistently take 400IU. Vitamin E has noticeably improved my blood flow and skin condition, reducing blemishes. It's convenient as I find it challenging to eat enough vitamin E-rich nuts daily.
Read More
6
Good blood circulation
3 people found this helpful
It's larger than Japanese variants, but I've become accustomed to it. I continue using this natural alpha-tocopherol vitamin E even though it's somewhat costly. Its quality is reputable, and my recent blood circulation test results are good, which I attribute to this product.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.4
- All Researches
9
Our exploration focused on how tocotrienols, a form of vitamin E, influence blood clotting, especially in the context of risk factors like stroke. Using a canine model, we assessed the effects of tocotrienols on platelet aggregation and thrombus formation.
The findings revealed that tocotrienols significantly inhibited both platelet thrombus formation and collagen-induced platelet aggregation. We noticed that tocotrienols could be converted to tocopherols, which might add to their effectiveness. Overall, these results suggest tocotrienols could offer a therapeutic advantage in preventing serious cardiovascular events.
The findings revealed that tocotrienols significantly inhibited both platelet thrombus formation and collagen-induced platelet aggregation. We noticed that tocotrienols could be converted to tocopherols, which might add to their effectiveness. Overall, these results suggest tocotrienols could offer a therapeutic advantage in preventing serious cardiovascular events.
Read More
9
We investigated whether vitamin E supplementation affects the risk of blood clots, specifically venous thromboembolism (VTE), in women. The Women's Health Study involved nearly 40,000 women who received either vitamin E or a placebo over more than ten years.
Our findings revealed that those taking vitamin E experienced a significant reduction in VTE occurrences compared to the placebo group. Notably, women with a history of VTE or certain genetic factors benefited the most from supplementation.
Overall, vitamin E may play a protective role against blood clots, offering promise for at-risk individuals.
Our findings revealed that those taking vitamin E experienced a significant reduction in VTE occurrences compared to the placebo group. Notably, women with a history of VTE or certain genetic factors benefited the most from supplementation.
Overall, vitamin E may play a protective role against blood clots, offering promise for at-risk individuals.
Read More
9
We explored the effects of vitamin E and sesamin on blood pressure and blood clot formation using young rats prone to stroke. The rats were divided into four groups: a control group, a vitamin E group, a sesamin group, and a combination group for five weeks.
Notably, the rats receiving vitamin E and sesamin showed lower blood pressure and thrombotic tendencies compared to the control group. However, while there was some reduction in clot formation, it was not substantial enough to conclude a significant clinical benefit.
Thus, we observed that while vitamin E and sesamin may have some protective effects, their impact on blood clot prevention is not definitively established.
Notably, the rats receiving vitamin E and sesamin showed lower blood pressure and thrombotic tendencies compared to the control group. However, while there was some reduction in clot formation, it was not substantial enough to conclude a significant clinical benefit.
Thus, we observed that while vitamin E and sesamin may have some protective effects, their impact on blood clot prevention is not definitively established.
Read More
9
We explored how vitamin E affects blood clot breakdown in patients suffering from coronary spastic angina. In a well-structured study, 40 participants were split into groups receiving either vitamin E or a placebo over a month.
We observed that those who took vitamin E experienced significant improvements, with decreased levels of a key clotting factor and a marker for oxidative stress. This suggests that vitamin E may serve as an effective addition to treatments for managing coronary spasms, especially in patients without coronary atherosclerosis.
We observed that those who took vitamin E experienced significant improvements, with decreased levels of a key clotting factor and a marker for oxidative stress. This suggests that vitamin E may serve as an effective addition to treatments for managing coronary spasms, especially in patients without coronary atherosclerosis.
Read More
8
We explored how inducing heme oxygenase-1 (HO-1) could impact blood clot formation in a mouse model. Through a series of tests, we observed that mice treated with a HO-1 inducer showed a significant delay in thrombus formation.
This effect was linked to the production of bilirubin and carbon monoxide, which have protective roles in the bloodstream. Interestingly, when we used a vitamin E analogue, it almost entirely restored this delay in clotting. Overall, these findings suggest that enhancing HO-1 activity may offer a promising approach to prevent undesirable blood clots.
This effect was linked to the production of bilirubin and carbon monoxide, which have protective roles in the bloodstream. Interestingly, when we used a vitamin E analogue, it almost entirely restored this delay in clotting. Overall, these findings suggest that enhancing HO-1 activity may offer a promising approach to prevent undesirable blood clots.
Read More
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Reduces arterial ridges
2 people found this helpful
Vitamin E seems to dissolve blood clots on arterial walls. I take it daily and highly recommend it.
Read More
7.5
Improved skin health
3 people found this helpful
I consistently take 400IU. Vitamin E has noticeably improved my blood flow and skin condition, reducing blemishes. It's convenient as I find it challenging to eat enough vitamin E-rich nuts daily.
Read More
6
Good blood circulation
3 people found this helpful
It's larger than Japanese variants, but I've become accustomed to it. I continue using this natural alpha-tocopherol vitamin E even though it's somewhat costly. Its quality is reputable, and my recent blood circulation test results are good, which I attribute to this product.
Read More
Frequently Asked Questions
7.5
Improved skin health
3 people found this helpful
I consistently take 400IU. Vitamin E has noticeably improved my blood flow and skin condition, reducing blemishes. It's convenient as I find it challenging to eat enough vitamin E-rich nuts daily.
7.5
Reduces arterial ridges
2 people found this helpful
Vitamin E seems to dissolve blood clots on arterial walls. I take it daily and highly recommend it.
9
We investigated whether vitamin E supplementation affects the risk of blood clots, specifically venous thromboembolism (VTE), in women. The Women's Health Study involved nearly 40,000 women who received either vitamin E or a placebo over more than ten years.
Our findings revealed that those taking vitamin E experienced a significant reduction in VTE occurrences compared to the placebo group. Notably, women with a history of VTE or certain genetic factors benefited the most from supplementation.
Overall, vitamin E may play a protective role against blood clots, offering promise for at-risk individuals.
Our findings revealed that those taking vitamin E experienced a significant reduction in VTE occurrences compared to the placebo group. Notably, women with a history of VTE or certain genetic factors benefited the most from supplementation.
Overall, vitamin E may play a protective role against blood clots, offering promise for at-risk individuals.
7
We examined how vitamin E influences bleeding risks in patients with nonvalvular atrial fibrillation undergoing anticoagulant therapy. In our retrospective study of 566 patients, higher levels of serum vitamin E were associated with increased bleeding events.
Specifically, those who experienced bleeding had significantly higher vitamin E concentrations compared to those who did not. This suggests that elevated vitamin E may predict a higher risk of hemorrhage in patients taking anticoagulants, prompting the need for further research to clarify this relationship with newer medications.
Specifically, those who experienced bleeding had significantly higher vitamin E concentrations compared to those who did not. This suggests that elevated vitamin E may predict a higher risk of hemorrhage in patients taking anticoagulants, prompting the need for further research to clarify this relationship with newer medications.
7
We investigated how tamoxifen affects blood clots in a rat model, focusing on the potential benefits of vitamin E treatment. Our study involved four groups of rats, with one receiving vitamin E alongside tamoxifen.
While we noted endothelial proliferation linked to tamoxifen, vitamin E appeared to reverse this effect. Surprisingly, no significant reduction in thrombus formation was found compared to control groups. Overall, our findings suggest further exploration of vitamin E in conjunction with tamoxifen is warranted.
While we noted endothelial proliferation linked to tamoxifen, vitamin E appeared to reverse this effect. Surprisingly, no significant reduction in thrombus formation was found compared to control groups. Overall, our findings suggest further exploration of vitamin E in conjunction with tamoxifen is warranted.
9
Our exploration focused on how tocotrienols, a form of vitamin E, influence blood clotting, especially in the context of risk factors like stroke. Using a canine model, we assessed the effects of tocotrienols on platelet aggregation and thrombus formation.
The findings revealed that tocotrienols significantly inhibited both platelet thrombus formation and collagen-induced platelet aggregation. We noticed that tocotrienols could be converted to tocopherols, which might add to their effectiveness. Overall, these results suggest tocotrienols could offer a therapeutic advantage in preventing serious cardiovascular events.
The findings revealed that tocotrienols significantly inhibited both platelet thrombus formation and collagen-induced platelet aggregation. We noticed that tocotrienols could be converted to tocopherols, which might add to their effectiveness. Overall, these results suggest tocotrienols could offer a therapeutic advantage in preventing serious cardiovascular events.
References
- Jafar Haeri SM, Dashti G, Mardani M, Rashidi B, Nikgoftar Fathi A, et al. Effect of Vitamin E on Apoptosis of the Endothelial Cells of the Carotid Arteries in Hypercholesterolemic Male Rabbits. ARYA Atheroscler. 2023;19:10. 10.48305/arya.2022.39175.2824
- Ho JI, Ng EY, Chiew Y, Koay YY, Chuar PF, et al. The effects of vitamin E on non-proliferative diabetic retinopathy in type 2 diabetes mellitus: Are they sustainable with 12 months of therapy. SAGE Open Med. 2022;10:20503121221095324. 10.1177/20503121221095324
- Ceran C, Aksam E, Aksam B, Yenidünya S, Suludere Z, et al. Tamoxifen-Related Thrombosis: An Experimental Study in Rat Venous Microvascular Anastomosis Model. Ann Plast Surg. 2017;78:213. 10.1097/SAP.0000000000000798
- Pastori D, Carnevale R, Cangemi R, Saliola M, Nocella C, et al. Vitamin E serum levels and bleeding risk in patients receiving oral anticoagulant therapy: a retrospective cohort study. J Am Heart Assoc. 2013;2:e000364. 10.1161/JAHA.113.000364
- Sasaki Y, Kobara N, Higashino S, Giddings JC, Yamamoto J. Astaxanthin inhibits thrombosis in cerebral vessels of stroke-prone spontaneously hypertensive rats. Nutr Res. 2011;31:784. 10.1016/j.nutres.2011.09.010
- Fahim MA, Nemmar A, Singh S, Hassan MY. Antioxidants alleviate nicotine-induced platelet aggregation in cerebral arterioles of mice in vivo. Physiol Res. 2011;60:695. PubMed
- Qureshi AA, Karpen CW, Qureshi N, Papasian CJ, Morrison DC, et al. Tocotrienols-induced inhibition of platelet thrombus formation and platelet aggregation in stenosed canine coronary arteries. Lipids Health Dis. 2011;10:58. 10.1186/1476-511X-10-58
- Ristow B. Preoperative use of alpha tocopherol does not increase the risk of hematoma in the face lift patient: a preliminary report. Plast Reconstr Surg. 2009;124:1696. 10.1097/PRS.0b013e3181b98a3a
- Ping-Chia L, I-Ju L, Yu-Ching L, Li-Ching C, Wen-Chung C. Substance P scavenger enhances antioxidant defenses and prevents prothrombotic effects on the rat lung after acute exposure to oil smoke. J Biomed Sci. 2009;16:58. 10.1186/1423-0127-16-58
- Glynn RJ, Ridker PM, Goldhaber SZ, Zee RY, Buring JE. Effects of random allocation to vitamin E supplementation on the occurrence of venous thromboembolism: report from the Women's Health Study. Circulation. 2007;116:1497. PubMed
- Singh I, Turner AH, Sinclair AJ, Li D, Hawley JA. Effects of gamma-tocopherol supplementation on thrombotic risk factors. Asia Pac J Clin Nutr. 2007;16:422. PubMed
- Allman-Farinelli MA, Dawson B. Diet and aging: bearing on thrombosis and hemostasis. Semin Thromb Hemost. 2005;31:111. PubMed
- Noguchi T, Ikeda K, Sasaki Y, Yamamoto J, Yamori Y. Effects of vitamin E and sesamin on hypertension and cerebral thrombogenesis in stroke-prone spontaneously hypertensive rats. Clin Exp Pharmacol Physiol. 2004;31 Suppl 2:S24. PubMed
- Miyamoto S, Kawano H, Takazoe K, Soejima H, Sakamoto T, et al. Vitamin E improves fibrinolytic activity in patients with coronary spastic angina. Thromb Res. 2004;113:345. PubMed
- Lindenblatt N, Bordel R, Schareck W, Menger MD, Vollmar B. Vascular heme oxygenase-1 induction suppresses microvascular thrombus formation in vivo. Arterioscler Thromb Vasc Biol. 2004;24:601. PubMed
Data last updated:
